犬病毒性呼吸道疾病及其病毒性病原之關係

Canine Viral Respiratory Disease and its Viral Pathogens

10.7042/JYDXTSXB.201012.0125

林凱揚(Kai-Yang Lin)；余章游(Chang-You Yu)；蘇耀期(Yao-Chi Su)；詹昆衛(Kun-Wei Chan)；沈昱名(Yu-Ming Shen)；賴治民(Jyh-Mirn Lai)

上呼吸道感染 ； 病原 ； 犬 ； upper respiratory infection ； pathogen ； dog

嘉義大學通識學報

8期（2010 / 12 / 01）

125 - 139

繁體中文

犬傳染性呼吸道疾病，是一種高接觸性傳染疾病，主要藉由飛沫傳播，好發在幼年及老年犬隻，造成上呼吸道的症狀，如咳嗽、流鼻水和呼吸困難。病毒病原主要有犬第二型副流感病毒（canineparainf1uenza virus type 2, CPiV-2）、犬瘟熱病毒（canine distemper virus, CDV）、犬呼吸道型冠狀病毒（canine respiratory coronavirus, CRCo V）、犬腺病毒第二型（canine adenovirus type 2, CAV-2）以及犬疱疹病毒（canine herpesvirus, CHV）。目前雖有疫苗可以施打，但此病爆發仍常發生。在診斷方面，主要藉由聚合酶連鎖反應（polymerase chain reaction, PCR），以及市面上已有的商業化檢驗套組可檢測眼鼻分泌物。在台灣已有針對犬呼吸道疾病病原的研究調查，但因地區、年齡及環境等因素的不同，其真實情形仍然需更多的研究來支持。本文將綜論病原之間的關係及病原流行病學的異同。

Canine infectious respiratory disease is a high contagious disease. The main transmission route is via infectious droplets. Generally, the disease occurs in younger and elder dogs, and causes upper respiratory syndromes, such as cough, nasal discharge and dyspnea. The viral pathogens are mainly canine parainfluenza virus type 2, canine distemper virus, canine respiratory coronavirus, canine adenovirus type 2, and canine herpesvirus. Although vaccines against the diseases are commercialized, the outbreaks are recorded often. Polymerase chain reaction and many commercial diagnostic kits, which detect viruses in dog's nasal discharge, are available. In Taiwan, some studies have been done to investigate the causative agents of this disease. However, because geographical, environmental and age factors are vary in different studies, a true image is still worthy of study. In this paper, the differences in conclusions in papers relating to the pathogens of this disease and its epidemiology are discussed.

1. DOG Breeding, Canine herpes virus infection, accessed date 2010/11/16, http://www.lowchensaustralia.com/breeding/herpes.htm
2. Bohm, M.,Thompson, H.,Weir, A.,Hasted, A.M.,Maxwell, N.S.,Herrtage, M.E.(2004).Serum antibody titres to canine parvovirus, adenovirus and distemper virus in dogs in the UK which had not been vaccinated for at least three years.Vet Rec,154(15),457-463.
3. Buonavoglia, C.,Martella,V.(2007).Canine respiratory viruses.Vet Res,38(2),355-373.
4. Castleman, W.L.(1985).Bronchiolitis obliterans and pneumonia induced in young dogs by experimental adenovirus infection.Am J Pathol,119(3),495-504.
5. Damian, M.,Morales, E.,Salas, G.,Trigo, F.J.(2005).Immunohistochemical detection of antigens of distemper, adenovirus and parainfluenza viruses in domestic dogs with pneumonia.J Comp Pathol,133(4),289-293.
6. Decaro, N.,Desario, C.,Elia, G.,Mari, V.,Lucente, M.S.,Cordioli, P.(2007).Serological and molecular evidence that canine respiratory coronavirus is circulating in Italy.Vet Microbiol,121(3-4),225-230.
7. Ditchfield, J.,Macpherson, L.W.,Zbitnew, A.(1962).Association of Canine Adenovirus (Toronto A 26/61) with an Outbreak of Laryngotracheitis ("Kennel Cough"): A Preliminary Report.Can Vet J,3(8),238-247.
8. Elia, G.,Decaro, N.,Martella, V.,Cirone, F.,Lucente, M.S.,Lorusso, E.(2006).Detection of canine distemper virus in dogs by real-time RT-PCR.J Virol Methods,136(1-2),171-176.
9. Erles, K.,Dubovi, E.J.,Brooks, H.W.,Brownlie, J.(2004).Longitudinal study of viruses associated with canine infectious respiratory disease.J Clin Microbiol,42(10),4524-4529.
10. Erles, K.,Shiu, K. B.,Brownlie, J.(2007).Isolation and sequence analysis of canine respiratory coronavirus.Virus Res,124(1-2),78-87.
11. Erles, K.,Toomey, C.,Brooks, H.W.,Brownlie, J.(2003).Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease.Virology,310(2),216-223.
12. Ford, B. F.(Ed.)(2006).Infectious diseases of the dog and cat.St. Louis, Mo.:Saunders Elsevier.
13. Henrickson, K.J.(2003).Parainfluenza viruses.Clin Microbiol Rev,16(2),242-264.
14. Mochizuki, M.,Yachi, A.,Ohshima, T.,Ohuchi, A.,Ishida, T.(2008).Etiologic study of upper respiratory infections of household dogs.J Vet Med Sci,70(6),563-569.
15. Murphy, F.A.(1999).Canine distemper Veterinary virology.San Diego, Calif.:Academic.
16. Pardo, I.D.,Johnson, G.C.,Kleiboeker, S.B.(2005).Phylogenetic characterization of canine distemper viruses detected in naturally infected dogs in North America.J Clin Microbiol,43(10),5009-5017.
17. Rodriguez-Tovar, L.E.,Ramirez-Romero, R.,Valdez-Nava, Y.,Nevarez-Garza, A.M.,Zarate-Ramos, J.J.,Lopez, A.(2007).Combined distemper-adenoviral pneumonia in a dog.Can Vet J,48(6),632-634.
18. Schoehn, G.,El Bakkouri, M.,Fabry, C.M.,Billet, O.,Estrozi, L.F.,Le, L.(2008).Three-dimensional structure of canine adenovirus serotype 2 capsid.J Virol,82(7),3192-3203.
19. Song, D.,Kang, B.,Lee, C.,Jung, K.,Ha, G.,Kang, D.(2008).Transmission of avian influenza virus (H3N2) to dogs.Emerg Infect Dis,14(5),741-746.
20. Weiss, S.R.,Navas-Martin, S.(2005).Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus.Microbiol Mol Biol Rev,69(4),635-664.
21. Yachi, A.,Mochizuki, M.(2006).Survey of dogs in Japan for group 2 canine coronavirus infection.J Clin Microbiol,44(7),2615-2618.
22. 莊惠菊(2009)。碩士論文(碩士論文)。台北市，國立台灣大學獸醫學研究所。
23. 黃宣憲(2005)。碩士論文(碩士論文)。台北市，國立台灣大學獸醫學研究所。
24. 黃瓊儀(2005)。碩士論文(碩士論文)。台北市，國立台灣大學獸醫學研究所。