Computer Simulation Analysis of Microchannel for a Continuous-Flow PCR Chip

連續流PCR晶片之微流道電腦模擬分析

10.29987/CCUHKJE.200606.0001

周賢民(San-Min Chou)

Microelectromechanical system MEMS ； Continuous-flow Polymerase Chain Reaction PCR chip ； Microchannel ； Top-down ； Bottom-up

華岡工程學報

20期（2006 / 06 / 01）

1 - 11

英文

本研究目的主要是以微機電設計軟體Coventor Ware分析文獻中連續流PCR晶片之模型，旨在比較相異流道剖面形狀對熱傳之影響並找出較佳剖面形狀之流道，以提供DNA複製所需之快速升降溫的能力。且利用Top-down及Bottom-up設計方式建立影響模型相關參數曲線，以期往後可應用此資料對晶片作最佳化設計。

The purpose of this study is to analyze the model of a continuous-Flow Polymerase Chain Reaction (PCR) chip with Coventor Ware software. The main idea was to compare the effects of different cross sections of channel and find out the better one for heat transfer. It offered the ability of fast heating and cooling rate when the DNA duplication process happened. Besides, the Top-down and Bottom-up methods to draw relative parameter curves of model was applied on this study.