麩醯胺酸與精胺酸補充品對感染病之影響

10.29793/TYHHHK.200505.0005

劉宗翰

麩醯胺酸 ； 精胺酸 ； 感染 ； 免疫

體育學系(所)刊

5期（2005 / 05 / 01）

21 - 24

繁體中文

感染病常發生於免疫力下降、營養不良時，病原包括病毒、寄生蟲、原生動物、細菌、腐敗作用等。麩醯胺酸與精胺酸補充品，對燒燙傷、癌症、人類免疫缺乏病毒感染、手術及重大創傷患者的免疫效果，能增加淋巴細胞數量，減少感染併發症，提高復原速率，免疫細胞代謝麩醯胺酸、精胺酸，產生大量自由基毒殺胞外、胞質液之微生物。長時間運動及過度訓練，血液中麩醯胺酸濃度減少，產生免疫抑制效果，補充麩醯胺酸，可提升肌肉麩醯胺酸濃度，維持免疫能力。燒燙傷、人類免疫缺乏病毒感染患者補充麩醯胺酸的免疫效果，研究數量有限仍需進一步探討，精胺酸補充品為複合配方需針對精胺酸作用研究確認，不同運動項目的蛋白質需求量不同，胺基酸補充品劑量亦需要進一步探討。

1. Brittenden J.,Park K. G.,Heys S. D.,Ross C.,Ashby J.,Ah-See A.(1994).L-arginine stimulates host defenses in patients with breast cancer.Surgery,115(2),205-212.
2. Chuntrasakul C.,Siltham S.,Sarasombath S.,Sittapairochana C.,Leowattana W.,Chockvivatanavanit S.(2003).Comparison of a immunonutrition formula enriched arginine, glutamine and omega-3 fatty acid, with a currently high-enriched enteral nutrition for trauma patients.Journal of the Medical Association of Thailand,86(6),552-561.
3. Daly J. M.,Lieberman M. D.,Goldfine J.,Shou J.,Weintraub F.,Rosato E. F.(1992).Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome.Surgery,112(1),56-67.
4. Field C. J.,Johnson I.,Pratt V. C.(2000).Glutamine and arginine: immunonutrients for improved health.Medicine & Science in Sports & Exercise,32,377-388.
5. Gottschlich M. M.,Jenkins M.,Warden G. D.,Baumer T.,Havens P.,Snook J. T.(1990).Differential effects of three enteral dietary regimens on selected outcome variables in burn patients.Jpen: Journal of Parenteral & Enteral Nutrition,14(3),225-236.
6. Hankard R. G.,Darmaun D.,Sager B. K.,D''amore D.,Parsons W. R.,Haymond M.(1995).Response of glutamine metabolism to exogenous glutamine in humans.American Journal of Physiology,269(4 Pt 1),663-670.
7. Houdijk A. P.,Rijnsburger E. R.,Jansen J.,Wesdorp R. I.,Weiss J. K.,Mccamish M. A.(1998).Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma.Lancet,352(9130),772-776.
8. Kemen M.,Senkal M.,Homann H. H.,Mumme A.,Dauphin A. K.,Baier J.(1995).Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: an immunologic evaluation of Impact.Critical Care Medicine,23(4),652-659.
9. Moore F. A.,Moore E. E.,Kudsk K. A.,Brown R. O.,Bower R. H.,Koruda M. J.(1994).Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding.Journal of Trauma-Injury Infection & Critical Care,37(4),607-615.
10. Newsholme E. A.,Calder P. C.(1997).The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal.Nutrition,13(7-8),728-730.
11. Ogle C. K.,Ogle J. D.,Mao J. X.,Simon J.,Noel J. G.,Li B. G.(1994).Effect of glutamine on phagocytosis and bacterial killing by normal and pediatric burn patient neutrophils.Jpen: Journal of Parenteral & Enteral Nutrition,18(2),128-133.
12. Parry-Billings M.,Evans J.,Calder P. C.,Newsholme E. A.(1990).Does glutamine contribute to immunosuppression after major burns?.Lancet,336(8714),523-525.
13. Parry-Billings M.,Preedy V.,Opara E.,Liu C. T.,Newsholme E. A.(1992).Acute ethanol administration and the metabolism of glutamine by skeletal muscle of the rat: implications for ethanol-induced reductions in protein synthesis.Alcohol & Alcoholism,27(6),613-618.
14. Suttmann U.,Ockenga J.,Schneider H.,Selberg O.,Schlesinger A.,Gallati H.(1996).Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support.Journal of the American Dietetic Association,96(6),565-569.
15. Weimann A.,Bastian L.,Bischoff W. E.,Grotz M.,Hansel M.,Lotz J.(1998).Influence of arginine, omega-3 fatty acids and nucleotide-supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma.Nutrition,14(2),165-172.
16. Yoshida S.,Matsui M.,Shirouzu Y.,Fujita H.,Yamana H.,Shirouzu K.(1998).Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer.Annals of Surgery,227(4),485-491.