威爾剛在高山運動能力的運用

10.29793/TYHHHK.201112.0002

施錫麟；陳裕鏞

第5型雙磷酸酯解酶抑制劑 ； 高海拔急性缺氧 ； 一氧化氮 ； 勃起

體育學系(所)刊

11期（2011 / 12 / 01）

13 - 21

繁體中文

在高海拔活動中，隨著高度的增加，伴隨周邊氧分壓下降、動脈氧壓下降、肺微血管收縮；嚴重時將出現嚴重高山症如肺水腫、腦水腫等致命危機。另高海拔運動中由於肺血管收縮，產生肺動脈高血壓，致心輸出量減少而影響到高海拔的運動能力。威爾剛（sildenafil citrate）特別具有對肺血管擴張的專一性，在六天內爬到4350公尺的高山，一天給予3次40毫克的威爾剛，實驗組明顯肺動脈壓低於控制組。整體而論，威爾剛確實可以預防、治療高山症的發生，並增加高（低）海拔急性低氧氣氛壓的運動能力。

1. Anand, I. S.,Chandrashekhar, Y.,Rao, S. K.,Malhotra, R. M.,Ferrari, R.,Chandana, J.(1993).Body fluid compartments, renal blood flow, and hormones at 6,000 m in normal subjects.Journal of Applied Physiology,74(3),1234-1239.
2. Bartsch, P.,Grunig, E.,Hohenhaus, E.,Dehnert, C.(2001).Assessment of high altitude tolerance in healthy individuals.High Altitude Medicine & Biology,2(2),287-296.
3. Boral, M. C.,Patra, P. B.(1981).Studies on the erythropoietic effect of testis of toad at a simulated high altitude (hypoxic exposure).Endokrinologie,78(1),35-40.
4. Braun, B.,Butterfield, G. E.,Dominick, S. B.,Zamudio, S.,McCullough, R. G.,Rock, P. B.(1998).Women at altitude: changes in carbohydrate metabolism at 4,300-m elevation and across the menstrual cycle.Journal of Applied Physiology,85(5),1966-1973.
5. Droma, Y.,Hanaoka, M.,Ota, M.,Katsuyama, Y.,Koizumi, T.,Fujimoto, K.(2002).Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema.Circulation,106(7),826-830.
6. El-Metwally, M. A.,Sharabi, F. M.,Daabees, T. T.,Senbel, A. M.,Mostafa, T.(2007).Involvement of alpha-receptors and potassium channels in the mechanism of action of sildenafil citrate.International Journal of Impotence Research,19(6),551-557.
7. Fu, Z.,Jiang, P.,Ren, Y.,Peng, S.,Li, H.,Luo, X.(2002).Changes of antioxidative capacity and endothelial function before and after treatment among patients with high altitude pulmonary edema.Zhonghua Jie He He Hu Xi Za Zhi,25(1),33-35.
8. Gallagher, S. A.,Hackett, P. H.(2004).High-altitude illness.Emergency Medicine Clinics of North America,22(2),239-355.
9. Ghofrani, H. A.,Reichenberger, F.,Kohstall, M. G.,Mrosek, E. H.,Seeger, T.,Olschewski, H.(2004).Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial.Annals of Internal Medicine,141(3),169-177.
10. Ghofrani, H. A.,Schermuly, R. T.,Rose, F.,Wiedemann, R.,Kohstall, M. G.,Kreckel, A.(2003).Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension.American Journal of Respiratory and Critical Care Medicine,167(8),1139-1141.
11. Ghofrani, H. A.,Wiedemann, R.,Rose, F.,Schermuly, R. T.,Olschewski, H.,Weissmann, N.(2002).Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial.Lancet,360(9337),895-900.
12. Gonzalez, G.,Celedon, G.,Escobar, M.,Sotomayor, C.,Ferrer, V.,Benitez, D.(2005).Red cell membrane lipid changes at 3,500 m and on return to sea level.High Altitude Medicine & Biology,6(4),320-326.
13. Guidetti, L.,Emerenziani, G. P.,Gallotta, M. C.,Pigozzi, F.,Di Luigi, L.,Baldari, C.(2008).Effect of tadalafil on anaerobic performance indices in healthy athletes.British Journal of Sports Medicine,42(2),130-133.
14. Hirata, K.,Adji, A.,Vlachopoulos, C.,O''Rourke, M. F.(2005).Effect of sildenafil on cardiac performance in patients with heart failure.The American Journal of Cardiology,96(10),1436-1440.
15. Hopkins, S. R.(2010).Stress failure and high-altitude pulmonary oedema: mechanistic insights from physiology.The European Respiratory Journal,35(3),470-472.
16. Hsu, A. R.,Barnholt, K. E.,Grundmann, N. K.,Lin, J. H.,McCallum, S. W.,Friedlander, A. L.(2006).Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia.Journal of Applied Physiology,100(6),2031-2040.
17. Kasper, W.,Konstantinides, S.,Geibel, A.,Tiede, N.,Krause, T.,Just, H.(1997).Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism.Heart,77(4),346-349.
18. Kimura, M.,Higashi, Y.,Hara, K.,Noma, K.,Sasaki, S.,Nakagawa, K.(2003).PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers.Hypertension,41(5),1106-1110.
19. Kothari, S. S.,Duggal, B.(2002).Chronic oral sildenafil therapy in severe pulmonary artery hypertension.Indian Heart Journal,54(4),404-409.
20. Lewis, G. D.,Shah, R.,Shahzad, K.,Camuso, J. M.,Pappagianopoulos, P. P.,Hung, J.(2007).Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension.Circulation,116(14),1555-1562.
21. Lim, P. H.,Moorthy, P.,Benton, K. G.(2002).The clinical safety of viagra.Annals of the New York Academy of Sciences,962,378-388.
22. Maggiorini, M.,Melot, C.,Pierre, S.,Pfeiffer, F.,Greve, I.,Sartori, C.(2001).High-altitude pulmonary edema is initially caused by an increase in capillary pressure.Circulation,103(16),2078-2083.
23. Mairbaurl, H.(2006).Role of alveolar epithelial sodium transport in high altitude pulmonary edema (HAPE).Respiratory Physiology & Neurobiology,151(2-3),178-191.
24. Richalet, J. P.,Gratadour, P.,Robach, P.,Pham, I.,Dechaux, M.,Joncquiert-Latarjet, A.(2005).Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension.American Journal of Respiratory and Critical Care Medicine,171(3),275-281.
25. Roach, J. M.,Schoene, R. B.(2002).Medical Aspects of Harsh Environments.Department of the Army.
26. Sheel, A. W.,MacNutt, M. J.,Querido, J. S.(2010).The pulmonary system during exercise in hypoxia and the cold.Experimental Physiology,95(3),422-430.
27. Voelkel, N. F.(2002).High-altitude pulmonary edema.The New England Journal of Medicine,346(21),1606-1607.
28. Zaidi, S. H.,You, X. M.,Ciura, S.,Husain, M.,Rabinovitch, M.(2002).Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension.Circulation,105(4),516-521.