成人口腔中非典型柏奇特氏淋巴瘤－類柏奇特氏淋巴瘤－病例報告

Adult Atypical/Burkitt-like Lymphoma in Oral Cavity-A Case Report

10.7104/TJOMS.200812.0283

柳昭蔚(Chao-Wei Liu)；郭松泊(S-B Kuo)；黃于真(Yu-Chen Huang)；張佑良(Yu-Liang Chang)

柏奇特氏淋巴瘤 ； 非典型柏奇特氏淋巴瘤 ； 類柏奇特氏淋巴瘤 ； Burkitt's lymphoma ； atypical Burkitt lymphoma ； Burkitt-like lymphoma

臺灣口腔顎面外科學會雜誌

19卷4期（2008 / 12 / 01）

283 - 292

繁體中文

柏奇特氏淋巴瘤源於B細胞癌化增生，是一種高度惡性的非霍金氏淋巴瘤。它的疾病發生率很低，在西方國家的報告中，每年的發生率約佔全部林巴瘤的1%到10%。柏奇特氏淋巴瘤好發的地區集中在非洲，發生率約是西方國家的20至40倍。根據世界衛生組織的分類，柏奇特氏淋巴瘤組織形態的特徵，除了典型的分類外，還可區分出兩種變異的林巴瘤：非典型柏奇特氏淋巴瘤／類柏奇特氏淋巴瘤以及具有似漿細胞分化的柏奇特氏淋巴瘤。本文中，我們將報告一例發生在成人口腔中的罕見非典型柏奇特氏淋巴瘤／類柏奇特氏淋巴瘤病例，其臨床的特徵近似多發性化膿性肉芽腫。我們也將進一步討論柏奇特氏淋巴瘤與非典型柏奇特氏淋巴瘤／類柏奇特氏淋巴瘤之間的鑑別診斷，以及兩者在組織形態、基因特徵與臨床特徵的異同。

Burkitt's lymphoma (BL) is a high-grade non-Hodgkin's lymphoma (NHL) of B-cell origin. The annual incidence of Burkitt's lymphoma (BL) is low. In western countries, the incidence is 1% to 10% of all lymphoma. The incidence in Africa is 20 to 40 times the incidence of wersten countries. According to the World Health Organization (WI-b) recent classification, Burkitt's lymphoma (BL) depending on its histomorphology is subdivided into classical BL, which includes 2 variants, the atypical Burkitt/Burkitt-like lymphoma (BLL) variant and Burkitt's lymphoma (BL) with plasmacytoid differentiation. In this article, we report an unusual case of adult atypical Burkitt/Burkitt-like lymphoma (BLL) presenting as multiple pyogenic granulomas in oral cavity and review the literature. Further discussion on the differential diagnosis of Burkitt's lymphoma (BL) and atypical Burkitt/Burkitt-like lymphoma (BLL), as well as its histologic features, genetic features and clinical features were presented.