题名

低強度脈衝超音波刺激於關節軟骨修復影響之研究

并列篇名

The Study of Low-Intensity Ultrasound Stimulates on Cartilage Repair

作者

鄭夏英(Hsia-Ying Cheng)；吳俊賢(Chun-Shien Wu)；張淑真(Shwu-Jen Chang)；楊善為(Shan-Wei Yang)

关键词

低強度脈衝超音波 ； 關節軟骨 ； 軟骨受損 ； low-intensity pulsed ultrasound ； cartilage injury

期刊名称

興大體育學刊

卷期/出版年月

13期（2014 / 01 / 01）

页次

83 - 90

内容语文

繁體中文
中文摘要

除了高齡化的影響外，近年來運動傷害，亦是造成軟骨受損退化病患增加的原因，因此膝關節軟骨的修復也逐年備受重視。低強度脈衝超音波（low-intensity pulsed ultrasound，LIPUS）已經被應用於治療骨折，促進不癒合的部位使其正常的癒合。相關研究顯示LIPUS具有促進軟骨代謝的特點，然而於體內對於軟骨的修復效用則是有待探討。因此，本研究以日本大白兔作為受損軟骨的動物模型，擬探討低強度脈衝超音波體外刺激對於關節軟骨組織之影響。研究中軟骨缺損模型是以手術的方式於日本大白免膝關節軟骨上製造缺陷，分為無接受LIPUS治療及接受LIPUS治療，最後以組織形態進行評估。初步結果顯示，經LIPUS治療與無LIPUS治療的組別相比，組織有較為顯著增生；然而，於軟骨缺損處軟骨細胞外基質，有經過LIPUS治療的組別並無顯著增生。本研究所使用的動物模型之軟骨損傷程度是較為嚴重程度，顯示LIPUS在嚴重的軟骨損傷上，修復效果並不顯著。
英文摘要

Chondral injuries are common lesions of the knee joint. Variety of causes leads to chondral degeneration, such as aging degeneration or sport injury. As known, low-intensity pulsed ultrasound (LIPUS) has been used to treat fractures with non-union and to promote bone repair. However, the effects of LIPUS on articular cartilage repair still remains unclear till today. In the present study, we investigated the application of LIPUS on the repair of articular cartilage in a rabbit cartilage injury model. The rabbits were divided into two groups, that is, experimental group (with-LIPUS-treatment) and control group (without-LIPUS-treatment). The preliminary results showed that the cartilage defects with-LIPUS-treatment groups had filled with the obvious regenerated tissue compared to the without-LIPUS-treatment groups. However, there was no significant difference on the formation of cartilage extracellular matrix between the with-LIPUS-treatment and without-LIPUS-treatment groups under the characteristic Alcian-blue stain assay. In summary, LIPUS has no significant therapeutic effect in treating severe articular cartilage injury from this animal study.
主题分类 社會科學 > 體育學
参考文献
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