Efficacy of ON101 cream, a Topical Macrophage-Regulating Cream, against Chronic Burn Wounds -- A Case Report and Literature Review

速必一乳膏用於燒傷慢性傷口之──個案報告

Ng Kwan Lok Benjamin(伍君樂)；I-Chien Chen(陳怡倩)；Bei-Ling Chen(陳蓓玲)；Shu-Hung Huang(黃書鴻)

ON101 cream ； burn wounds ； steroid ； case report

臺灣整形外科醫學會雜誌

33卷2期（2024 / 06 / 01）

199 - 206

英文;繁體中文

Background: Individuals with flame burns experience long-term morbidity, and delayed wound healing has both physical and mental repercussions. Various strategies are used in the treatment of chronic wounds; however, no consensus has been achieved regarding the optimal approach to such treatment. ON101, a topical cream comprising Plectranthus amboinicus and Centella asiatica, has recently emerged as an alternative therapeutic option for chronic wounds. This cream regulates macrophage subtypes and exerts anti-inflammatory effects. Although numerous studies have reported the healing effects of ON101 on diabetic wounds, few studies have investigated its effects on burn wounds. Aim and Objectives: A 26-year-old woman presented to our clinic with a chronic burn wound behind her left ear. She sustained the wound during a chemistry experiment. Despite receiving wound care for more than six months, the patient could not achieve complete wound healing. We prescribed ON101 cream and monitored the wound closely. This case report and literature review aims to present the therapeutic impact of ON101 cream on chronic burn wound of a 26-year-old female who was flame burned during an experiment. Materials and Methods: The patient independently performed wound dressing at home for 3 weeks. Her recovery was documented through photographs taken during the treatment and throughout the follow-up period. Results: Treatment with ON101 cream resulted in wound healing without any side effects. The patient was satisfied with posttreatment aesthetic outcomes. Conclusion: Our report, coupled with a literature review, highlights the therapeutic benefits of ON101 cream for patients with chronic burn wounds. ON101 may be used as a topical agent for such patients.

背景：燒燙傷病人需要面對長期的併發症。延遲的傷口癒合不僅會影響患者的身體，還會影響病人心理狀況。現在有多種治療慢性傷口的方法，但最佳治療方案仍在爭論中。速必一乳膏是一種含有左手香和積雪草成分的外用製劑，通過調節巨噬細胞的型態和改善發炎反應，達到治療慢性傷口的方法。大量研究報導速必一乳膏對糖尿病傷口有良好的治療效果，但目前尚無研究報導其對燒燙傷傷口的效果。目的及目標：我們描述一名26歲的女性，主訴為左側耳後區域有一慢性燒燙傷傷口。儘管傷口治療了半年多，但癒合狀況仍不佳。本病例報告以速必一乳膏來治療一名26歲女性的慢性燒燙傷傷口，達到很好的治療效果。材料及方法：這名26歲女性接受速必一乳膏治療其左耳後區域之慢性傷口。結果：使用速必一乳膏三週後，傷口順利癒合，沒有明顯的副作用。結論：速必一乳膏可調節巨噬細胞亞型並降低發炎反應。其功效可有效治療慢性燒燙傷傷口。對於患有慢性燒燙傷傷口的患者，速必一乳膏可以達到治療的效果。