全乳房超音波電腦輔助偵測之臨床應用分析

陳榮泰

doi:10.6342/NTU201701595

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全乳房超音波电脑辅助侦测之临床应用分析

Clinical Utility of Computer-aided Detection in Whole Breast Ultrasound

陈荣泰 , 博士　　导师：张瑞峰　　

英文 DOI： 10.6342/NTU201701595

乳癌；乳癌筛检；自动乳房超音波；比较性研究；全乳房超音波；电脑辅助侦测； Breast cancer ； Screening ； Automated breast ultrasound ； Comparative study ； Whole-breast ultrasound ； Computer-aided detection

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摘要 │ 参考文献 (63) │ 国际计量

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The incidence of breast cancer is increasing worldwide, reinforcing the importance of breast screening. Conventional hand-held ultrasound (HHUS) for breast screening is efficient and relatively easy to perform; however, limited by operator dependency and non-reproducible results. Thus, whole-breast ultrasound (WBUS) and 3-D automated breast ultrasound (ABUS) were developed to overcome these problems. However, reviewing hundreds of slices in a 3-D ABUS image to find suspicious is time-consuming. To reduce the midsection and accelerate the reviewing procedure by physicians, computer-aided detection (CADe) systems were proposed to assist physicians in interpretation of ABUS images. Most of the previous studies for development of WBUS and CADe system have excellent performance in their data sets, but lack of clinical validity and clinical utility assessment. In the thesis, two clinical utility studies for WBUS and CADe system were proposed. In the first study, an electromagnetic tracking-based whole-breast ultrasound system was investigated to facilitate the use of HHUS for breast screening. Subsequently, a multi-reader multi-case (MRMC) clinical retrospective reader study of CADe for ABUS was investigated. The results showed that WBUS is a practical clinical tool for breast screening that can be used instead of the often unavailable and costly ABUS, and the CADe system has the potential to be an effective second reader for detecting breast tumors in ABUS images.

参考文献 ( 63 ) 〈TOP〉

[1] F. Kamangar, G. M. Dores, and W. F. Anderson, "Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world," Journal of Clinical Oncology, vol. 24, pp. 2137-2150, May 10 2006.
连结：
[2] L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, "Global Cancer Statistics, 2012," Ca-a Cancer Journal for Clinicians, vol. 65, pp. 87-108, Mar-Apr 2015.
连结：
[3] R. L. Siegel, K. D. Miller, and A. Jemal, "Cancer Statistics, 2016," Ca-a Cancer Journal for Clinicians, vol. 66, pp. 7-30, Jan-Feb 2016.
连结：
[4] A. Takemura, A. Shimizu, and K. Hamamoto, "Discrimination of Breast Tumors in Ultrasonic Images Using an Ensemble Classifier Based on the AdaBoost Algorithm With Feature Selection," Ieee Transactions on Medical Imaging, vol. 29, pp. 598-609, Mar 2010.
连结：
[5] M. S. Soo, E. L. Rosen, J. A. Baker, T. T. Vo, and B. A. Boyd, "Negative predictive value of sonography with mammography in patients with palpable breast lesions," American Journal of Roentgenology, vol. 177, pp. 1167-1170, Nov 2001.
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使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。