Absent Effect of Zinc Deficiency on the Oxidative Stress of Erythrocytes in Chronic Uremic Rats

Shu-Ming Chen; Ching-Chu Wang; Fanny Lin; Tze-Kong Young

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P9 - 17

医药卫生 > 基础医学

DOI： 10.4077/CJP

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Absent Effect of Zinc Deficiency on the Oxidative Stress of Erythrocytes in Chronic Uremic Rats

Shu-Ming Chen ； Ching-Chu Wang ； Fanny Lin ； Tze-Kong Young

The Chinese Journal of Physiology ； 45 卷 1 期 (2002 / 03 / 01) ， P9 - 17

英文

Zinc ； selenium ； antioxidant enzymes ； osmotic fragility ； lipid peroxidation

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摘要 │ 参考文献 (60) │ 国际计量

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Both anemia and zinc deficiency are commonly observed in patients with chronic uremia. Oxidative stress of red blood cells (RBC) has been suggested to participate in the development of anemia in these patients with chronic uremia due to reduced life span of RBC. Whether zinc deficiency aggravates the effect of oxidative stress on RBC of chronic uremia is still not understood. We thus performed the study to determine the influence of zinc deficiency on the oxidative stress of RBC in uremic rats. Zinc deficiency was induced by long-term dietary zinc deficiency. Five-sixth nephrectomy (5/6 Nx) was used to produce chronic uremia. Experiment was carried out in the following five groups: normal control (NL), chronic uremia (Nx), chronic uremia + dietary zinc deficiency (Nx-D), Nx-D + zinc supplement (Nx-DZ) and Chronic uremia + pair-fed (Nx-PF). Osmotic fragility and lipid peroxidation of RBC were used to evaluate the oxidative stress of RBC. Five weeks after 5/6 nephrectomy (Nx), 5/6 Nx rats present a syndrome of uremia to elevate the levels of plasma creatinine and urea, and reduce the level of plasma zinc (1.12 ± 0.08 vs 1.35 ± 0.05 ug/ml). But they does not find to produce anemia and to increase osmotic fragility and lipid peroxidation in RBC. Dietary zinc deficiency in Nx-D group produced severe anorexia and reduced plasma zinc and selenium levels and the activity of RBC-GPX. Yet in Nx-D rats, osmotic fragility and susceptibility of lipid peroxidation in red cells did not increase, because of the increase of plasma copper level (1.85±0.3 vs 1.41±0.05 ug/ml) and RBC-SOD activity (1.95 ± 0.27 vs 0.78 ± 0.05 unit/g Hb). Zinc supplement in Nx-D rats (Nx-DZ group) recovered the appetite and normalized the levels of plasma zinc, copper and selenium. Food restriction in 5/6 Nx rats (Nx-PF group) decreased plasma copper level and increased osmotic fragility of RBC and elevated the susceptibility of lipid peroxidation after stressing RBC with H2O(subscript r). Because Nx-PF rats presented a lower RBC-SOD activity (0.44±0.11 vs 0.78±0.05 unit/g Hb) and a lower plasma copper level We further found a positive relationship (r=0.802, p＜0.0l) between plasma copper level and RBC-SOD activity in normal and uremic rats. This study suggests that RBC-SOD activity may play an important role in preventing RBC oxidative stress. Plasma copper level may be a marker of RBC-SOD activity. We conclude, in chronic uremia, zinc deficiency doses not result in RBC oxidative stress as plasma copper level is normal, but may affect the absorption of intestinal nutrition.

参考文献 ( 60 ) 〈TOP〉

Abdallah, S.M.,Samman, S.(1993).The effect of increasing dietary zinc on the activity of superoxide dismutase and zinc concentration in erythrocytes of healthy female subjects.Eur. J. Clin. Nutr,47,327-332.
Aebi, H.,Laszlo, L(1974).Catalase In Methods of Enzymatic Analysis.New York:Academic Press.
Bettger, W.,O``Dell, B.L.(1981).A critical physiological role of zinc in the structure and function of biomembranes.Life Sci,28,1425-1438.
Bettger, W.J.,Fish, T.J.,O`Dell, B.L.(1978).Effect of copper and zinc status of rats on erythrocyte stability and superoxide dismutase activity.Pro. Soc. Exp. Bio. Med,158,279-282.
Bettger, W.J.,O`Dell, B.L.(1993).Physiological role of zinc in the plasma membrane of mammalian cells.J. Nutr. Biochem,4,194-207.

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