Combination of Exercise Training and Resveratrol Attenuates Obese Sarcopenia in Skeletal Muscle Atrophy

Chyi-Huey Bai; Javad Alizargar; Ching-Yi Peng; Jia-Ping Wu

doi:10.4103/CJP.CJP_95_19

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医药卫生 > 基础医学

DOI： 10.4077/CJP

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Combination of Exercise Training and Resveratrol Attenuates Obese Sarcopenia in Skeletal Muscle Atrophy

Chyi-Huey Bai ； Javad Alizargar ； Ching-Yi Peng ； Jia-Ping Wu

The Chinese Journal of Physiology ； 63 卷 3 期 (2020 / 06 / 30) ， P101 - 112

英文 DOI： 10.4103/CJP.CJP_95_19

Exercise training ； obese sarcopenia ； obesity ； resveratrol ； sarcopenia

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摘要 │ 参考文献 (29) │ 国际计量

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Obese sarcopenia is a progressive loss of skeletal muscle mass and strength with increases in adipocytes. The aim of this study was to investigate the effects of combination of exercise training and resveratrol on the pathological pathway from obesity to sarcopenia, and potential therapy for skeletal muscle declines in physical function. Two animal models were experimented: (1) C57BL/6J male mice were fed either a high-fat diet (HFD) for 8 weeks to induce obesity and resveratrol (low-, middle-, and high-dose) for 4 weeks. (2) senescence-accelerated mouse prone 8 (SAMP8) mice with sarcopenia were used. Skeletal muscle function of SAMP8 mice expressed an age-associated decline. In SAMP8 mice, resveratrol (150 mg/Kg BW, daily) was administered by oral gavage two times a week for 1 month of the experimental period. Exercise training based on adaptations in the muscle is training twice a week for 4 weeks. SAMP8 mouse skeletal muscle in each group was analyzed by H and E staining, transferase dUTP nick end labeling, and Western blot analysis. Mitochondrial function expression, apoptosis and relative hypertrophy signaling in HFD-induced obesity mice and SAMP8 mice were determined by Western blot analysis. Results of the present study indicate that effect of resveratrol on skeletal muscles of HFD-induced obesity mice is linked to an increase in Bcl-2 and phosphatidylinositol 3 kinase/AKT expressions. On the other hand, resveratrol, and its combination with exercise training, attenuate the aging-related mitochondrial dysfunction involving Bad, caspase 3, and interleukin-6 expressions in SAMP8 mice. Combination of exercise training and resveratrol induced hypertrophy in skeletal muscles of sarcopenia SAMP8 mice. Therefore, we suggest combination of exercise training and resveratrol as a therapeutic potential in obese sarcopenia.

参考文献 ( 29 ) 〈TOP〉

Aubrey, J,Esfandiari, N,Baracos, VE,Buteau, FA,Frenette, J,Putman, CT(2014).Measurement of skeletal muscle radiation attenuation and basis of its biological variation.Acta Physiol,201,489-497.
Balachandran, A,Krawczyk, SN,Potiaumpai, M,Signorile, JF(2014).High-speed circuit training vs. hypertrophy training to improve physical function in sarcopenic obese adults: A randomized controlled trial.Exp Gerontol,60,64-71.
Chen, G,Ye, G,Zhang, X,Liu, X,Tu, Y,Ye, Z(2018).Metabolomics reveals protection of resveratrol in diet-induced metabolic risk factors in abdominal muscle.Cell Physiol Biochem,45,1136-1148.
Chen, HT,Chung, YC,Chen, YJ,Ho, SY,Wu, HJ(2017).Effects of different types of exercise on body composition, muscle strength, and IGF-1 in the elderly with sarcopenic obesity.J Am Geriatr Soc,65,827-832.
Choi, WH,Son, HJ,Jang, YJ,Ahn, J,Jung, CH,Ha, TY(2017).Apigenin ameliorates the obesity-induced skeletal muscle atrophy by attenuating mitochondrial dysfunction in the muscle of obese mice.Mol Nutr Food Res,61,1700218.

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