Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study

Chaucer Chiao-Hsiang Lin; Cheng-Cheng Hsiao; Yu-Shu Huang; Shao-Chun Ree; Mong-Liang Lu; Ruu-Fen Tzang; Sy-Ueng Luu; Teena Maree West; Winston W. Shen

doi:10.29478/TJP.201006.0005

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P110 - 121

医药卫生 > 社会医学

DOI： 10.29478/TJP

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Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study

精神分裂症门诊病人的临床特徵及治疗中断之研究：「洲际精神分裂症门诊病患健康结果研究」中台湾样本之分析

林乔祥(Chaucer Chiao-Hsiang Lin) ；萧正诚(Cheng-Cheng Hsiao) ；黄玉书(Yu-Shu Huang) ；吕少钧(Shao-Chun Ree) ；卢孟良(Mong-Liang Lu) ；臧汝芬(Ruu-Fen Tzang) ；鲁思翁(Sy-Ueng Luu) ； Teena Maree West ；沈武典(Winston W. Shen)

台湾精神医学； 24 卷 2 期 (2010 / 06 / 01) ， P110 - 121

英文 DOI： 10.29478/TJP.201006.0005

精神分裂症；观察性研究；治疗中断时间； Olanzapine ； schizophrenia ； observational study ； time to discontinuation ； olanzapine

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摘要 │ 参考文献 (30) │ 被引用文献 (1) │ 国际计量

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Objective: This report was to present the demographic and clinical outcomes of the Taiwanese cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study for the readership of Taiwanese psychiatrists. Methods: The IC-SOHO was a three-year, naturalistic, prospective, observational study which was designed to compare outcomes of outpatients with schizophrenia who had initiated or changed antipsychotic medications. They were divided into olanzapine and other non-olanzapine antipsychotic groups. Evaluations included clinical severity, social functioning, health-related quality of life, and medication tolerability. Time to treatment discontinuation was analyzed using the Kaplan-Meier method. Results: A total of 300 patients was enrolled in this Taiwanese cohort, and 81.6% (245 patients) of them received initial antipsychotic monotherapy. Despite the absence of randomization in this study, no significant differences were found between the treatment cohorts in the socio-demographic and clinical characteristics at baseline of those two groups. The mean doses of treatments were increased in those two groups over the 36-month period and the uses of non-antipsychotic concomitant medications remained high throughout the study. Patients who remained at the end of the study showed a clinical response to treatment indicated by reductions in CGI-S scores in all domains, but these changes were not significantly different between those two groups. The estimated time to medication discontinuation for 50% of patients was 36.3 (95% CI 31.2, 38.4) months for those in the olanzapine group and 18.0 (95% CI 11.3, 30.1) months for patients receiving other monotherapy; the hazard ratio was 0.65 (95% CI 0.43, 0.99). But their weight gain was signifi cantly greater for the olanzapine group over the first 12 months of treatment. Conclusion: The results of this naturalistic, observational study offer an important description of the clinical characteristics and outcomes associated with the long-term use of antipsychotic treatment of schizophrenia in a cohort of Taiwanese patients.

参考文献 ( 30 ) 〈TOP〉

Allison, D.B.,Casey, D.E.(2001).Antipsychotic-induced weight gain: a review of the literature.J Clin Psychiatry,62(Suppl 7),22-31.
American Psychiatric Association(1997).Practice guideline for the treatment of patients with schizphrenia.Am J Psychiatry,154(Suppl 2),1-63.
Ascher-Svanum, H.,Faries, D.E.,Zhu, B.,Ernst, F.R.,Swartz, M.S.,Swanson, J.W.(2006).Medication adherence and long-term functional outcomes in the treatment of schizophrenia in usual care.J Clin Psychiatry,67,453-60.
Basson, B.R.,Kinon, B.J.,Tor, C.C.,Szymanski, K.A.,Gilmore, J.A.,Tollefson, G.D.(2001).Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone.J Clin Psychiatry,62,231-8.
Bobes, J.,Rejas, J.,Garcia-Garcia, M.(2003).Weight gain in patients with schizophrenia treated with risperidone, olanzapine, quetiapine or haloperidol: results of the EIRE study.Schizophr Res,62,77-88.

被引用文献 ( 1 ) 〈TOP〉

Wu, Yu-Hsuan,Lai, Chun-Yang,Huang, Yu-Hui,Huang, Mei-Feng,Chang, Yu-San(2013).Changing Patterns of Antipsychotic Prescription and Concomitant Antiparkinson Drug Use at a Taiwanese Psychiatric Hospital.台湾精神医学,27(4),306-317.

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