磁振造影衍生細胞外體積分數與肥厚型心肌病患者之心室壁厚度關聯性分析

楊舜仲; 黃昱森; 陳怡臻; 魏淑圓; 莊志明; 蘇茂源

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P2105 - 2112

医药卫生 > 医药总论
工程学 > 核子工程
工程学 > 化学工业

DOI： 10.29832/TJARI

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磁振造影衍生细胞外体积分数与肥厚型心肌病患者之心室壁厚度关联性分析

CMR-Derived Extracellular Volume Fraction is Associated with the Ventricular Wall Thickness in Patients with Hypertrophic Cardiomyopathy

杨舜仲(Shun-Chung Yang) ；黄昱森(Yu-Sen Huang) ；陈怡臻(Yi-Chen Chen) ；魏淑圆(Shwu-Yuan Wei) ；庄志明(Jyh-Ming Juang) ；苏茂源(Mao-Yuan Su)

台湾应用辐射与同位素杂志； 17 卷 2 期 (2021 / 06 / 01) ， P2105 - 2112

繁体中文

细胞外体积分率；肥厚型心肌病；心血管磁振造影； ECV ； HCM ； CMR

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摘要 │ 参考文献 (12) │ 国际计量

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Hypertrophic cardiomyopathy (HCM) is hereditary cardiomyopathy that is characterized by left ventricular hypertrophy (LVH). LVH can develop in response to some factors, such as hypertension, aortic stenosis, or diffuse myocardial fibrosis (DMF). Cardiovascular magnetic resonance (CMR) has been widely used to quantify DMF by calculating the extracellular volume fraction (ECV) of the myocardium. Our aim was to investigate whether the severity of ventricular hypertrophy is associated with the degree of DMF in patients with HCM. Patients with HCM (n=125) and Brugada syndrome which was considered as the relative normal heart control (n=58) were retrospectively enrolled in this study. Pre- and postcontrast T1 maps and Cine images were acquired at 1.5T for the assessment of ECV and wall thickness (WT). ECV and WT measurements at 4 different regions, including the anterior, septal, posterior, and lateral wall regions, were measured, and all groups were compared. Regional ECV was correlated with the corresponding regional WT. Group comparison between two groups in ECV and WT were analyzed with the Mann-Whitney U test. Spearman was used to obtain a correlation coefficient between regional ECV and WT. The statistical tests were two-tailed, and statistical significance was defined as p ＜ 0.05.For the group comparison, HCM patients showed a significantly higher WT compared to that in controls (11.3±5.1 mm vs. 6.0±2.2 mm, p＜0.001). In addition, HCM patients also revealed significantly higher ECV compared to that in controls (27.5±4.9% vs. 25.0±2.3%, p＜0.001). The average ECV was significantly correlated with the average WT in patients with HCM (r=0.46, p＜0.001). In this study, we demonstrated that HCM patients with higher WT compared with controls. This finding supports that HCM patients have significant LVH. The increased ECV was positively associated with the corresponding regional wall thickness. This finding suggests that the severity of LVH might be associated with the degree of DMF in patients with HCM.

参考文献 ( 12 ) 〈TOP〉

Alcalai, R,Seidman, JG,Seidman, CE(2008).Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics.Journal of cardiovascular electrophysiology,19(1),104-110.
Galati, G,Leone, O,Pasquale, F(2016).Histological and histometric characterization of myocardial fibrosis in end-stage hypertrophic cardiomyopathy: a clinical-pathological study of 30 explanted hearts.Circulation: Heart Failure,9(9),003090.
Galati, G,Leone, O,Pasquale, F(2016).Histological and histometric characterization of myocardial fibrosis in end-stage hypertrophic cardiomyopathy: a clinical-pathological study of 30 explanted hearts.Circulation: Heart Failure,9(9),e003090.
Hindieh, W,Weissler-Snir, A,Hammer, H,Adler, A,Rakowski, H,Chan, RH(2017).Discrepant measurements of maximal left ventricular wall thickness between cardiac magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy.Circulation: Cardiovascular Imaging,10(8),e006309.
Kawel, N,Nacif, M,Zavodni, A,Jones, J,Liu, S,Sibley, CT,Bluemke, DA(2012).T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region.Journal of Cardiovascular Magnetic Resonance,14(1),1-10.

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