痰濁中阻型帕金森氏病中西醫結合診療之研究

吳哲豪; Che-Hao)

doi:10.6528/CAMS.2016.0003

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医药卫生 > 中医药学

DOI： 10.6528/CAMS

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痰浊中阻型帕金森氏病中西医结合诊疗之研究

Integrated TCM and Western Medicine Diagnosis and Treatment of phlegm turbidity obstructing the center pattern of Parkinson's Disease

吴哲豪(Wu ； Che-Hao)

中国鍼灸学杂志； 4 卷 1 期 (2016 / 12 / 11) ， P44 - 63

繁体中文 DOI： 10.6528/CAMS.2016.0003

帕金森氏病；半夏天麻白术汤； UPDRS评分；改良的Hoehn-Yahr分级； Parkinson's disease (PD) ； Ban Xia Tian Ma Bai Zhu tang ； unified Parkinson's disease rating scale (UPDRS) ； modified Hoehn-Yahr (H-Y) scale

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摘要 │ 参考文献 (20) │ 国际计量

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Purpose： Parkinson's disease(PD) typically presents in patients over 60 years old. Taiwan is an island with a humid and damp climate and eating habits of consuming fatty and sweet rich foods. These factors result in phlegm turbidity obstructing the center pattern presenting as the predominating type of PD. An evidencebased medicine (EBM) approach is applied to assess the efficacy and safety of administering Ban Xia Tian Ma Bai Zhu Tang variant for the treatment of PD patients, and a summary of the integrated TCM and Western medicine etiology and pathomechanism provided. The results of this study will provide a better reference source for the TCM treatment of PD. Material and method： This study entails a random distribution of patients in northern Taiwan's New Taipei City municipality with phlegm turbidity obstructing the center pattern type of PD. The treatment group consisted of 26 patients and the control group 24 patients. The control group continued to be administered Western medicine drug treatment and the treatment group was administered Ban Xia Tian Ma Bai Zhu Tang variant. The period of treatment assessed for both groups was 6 months. Observations were made on the clinical efficacy and unified Parkinson's disease rating scale (UPDRS) and modified Hoehn-Yahr (H-Y) scale before and after treatment in both groups. Comparative evaluations were made on the efficacy of TCM treatment and safety. Results： 1. The treatment group's UPDRS and clinical efficacy was markedly better than the control group (P＜ 0.05). 2. The pre- and post-treatment H-Y scale did not show discernible differences (P＞ 0.05). 3. The administration of Ban Xia Tian Ma Bai Zhu Tang variant had no deleterious effects on the liver or kidneys. Conclusion： 1. The administration of Ban Xia Tian Ma Bai Zhu Tang variant proved effective in treating PD patients and there were only marginal adverse effects. This treatment effectively controlled the symptoms of PD and lowered the UPDRS score, providing an optimized PD treatment approach that achieves the goal of delaying the onset of severe symptoms that affect quality of life. 2. The PD pattern types in Taiwan can be identified as follows: qi vacuity and blood stasis, phlegm turbidity obstructing the center, dual qi and blood vacuity, and dual yin and yang vacuity. The historical literature involving the administration of Ban Xia Tian Ma Bai Zhu Tang in the treatment of PD is also discussed. 3. The actions and adverse effects of the most commonly administered Western medicine drugs for the treatment of PD negatively impact and in some cases severely compromise a patients' quality of life. The advantages of administering TCM medicinals in the treatment of PD, the potential for singularly administering TCM medicinals in the treatment of PD in the absence of Western medicine drug administration, and how the administration of TCM medicinals substantially reduces the negative effects and adverse reactions of Western medicine drugs in order to improve the patients quality of life.

参考文献 ( 20 ) 〈TOP〉

de Lau, LM,Breteler, MM(2006).Epidemiology of Parkinson's disease.Lancet Neurol,5(6),525-535.
Deuschl, G,Schade-Brittinger, C,Krack, P(2006).A randomized trial of deep-brain stimulation for Parkinson's disease.N Engl J Med,355,896.
Fasano, A,Daniele, A,Albanese, A(2012).Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation.Lancet Neurol,11,429.
Gibb, WR,Lees, AJ(1988).The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.J Neurol Neurosurg Psychiatry,51,745.
Hornykiewicz, O(2006).The discovery of dopamine deficiency in the parkinsonian brain.J Neural Transm Suppl,70,9.

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