Exploration of the anticandidal mechanism of Cassia spectabilis in debilitating candidiasis

Angeline Torey; Soundararajan Vijayarathna; Subramanion L. Jothy; Sivapragasam Gothai; Yeng Chen; Lachimanan Yoga Latha; Jagat R. Kanwar; Saravanan Dharmaraj; Sreenivasan Sasidharan

doi:10.1016/j.jtcme.2014.11.017

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P73 - 80

医药卫生 > 中医药学

DOI： 10.1016/j.jtcme

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Exploration of the anticandidal mechanism of Cassia spectabilis in debilitating candidiasis

Angeline Torey ； Soundararajan Vijayarathna ； Subramanion L. Jothy ； Sivapragasam Gothai ； Yeng Chen ； Lachimanan Yoga Latha ； Jagat R. Kanwar ； Saravanan Dharmaraj ； Sreenivasan Sasidharan

Journal of Traditional and Complementary Medicine ； 6 卷 1 期 (2016 / 01 / 01) ， P73 - 80

英文 DOI： 10.1016/j.jtcme.2014.11.017

Anticandidal mechanism ； Cell wall protein ； Glucosidase ； Morphology ； Potassium leakage ； Proteinase

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摘要 │ 参考文献 (53) │ 被引用文献 (1) │ 国际计量

摘要〈TOP〉

Candida albicans has become resistant to the commercially available, toxic, and expensive anti-Candida agents that are on the market. These factors force the search for new antifungal agents from natural resources. Cassia spectabilis had been traditionally employed by healers for many generations. The possible mechanisms of the C. spectabilis leaf extract were determined by potassium leakage study and the effect of the extract on the constituents of the cell wall and enzymes as well as the morphological changes on C. albicans cells were studied along with cytotoxicity assays. The cytotoxicity result indicated that the extract is nontoxic as was clearly substantiated by a half maximal inhibitory concentration (IC_(50)) value of 59.10 mg/mL. The treated cells (C. spectabilis extract) demonstrated potassium leakage of 1039 parts per million (ppm) compared to Amphotericin B (AmpB)-treated cells with a released potassium value of 1115 ppm. The effects of the extract on the cell wall proteins illustrated that there were three major types of variations in the expression of treated cell wall proteins: the presence of new proteins, the absence of proteins, and the amount of expressed protein. The activities of two enzymes, α-glucosidase and proteinase, were determined to be significantly high, thereby not fully coinciding with the properties of the antifungal reaction triggered by C. spectabilis. The morphology of C. albicans cells treated with the C. spectabilis extract showed that the cells had abnormalities and were damaged or detached within the microcolonies. Our study verifies C. spectabilis leaf extract as an effective anti-C. albicans agent.

参考文献 ( 53 ) 〈TOP〉

Arya, V,Yadav, S,Kumar, S,Yadav, JP(2010).Antimicrobial activity of Cassia occidentalis L (leaf) against various human pathogenic microbes.Life Sci Med Res.,9,1-12.
Bourdeau, P(ed.),Somers, E(ed.),Richardson, GM(ed.),Hickman, JR(ed.)(1990).Short-Term Toxicity Tests for Non-Genotoxic Effects.New York, NY:John Wiley & Sons.
Bramono, K,Tsuboi, R,Ogawa, H(1995).A carbohydrate-degrading enzyme from Candida albicans: correlation between alpha-glucosidase activity and fungal growth.Mycoses,38,349-353.
Bramono, K,Yamazaki, M,Tsuboi, R,Ogawa, H(2006).Comparison of proteinase, lipase and alpha- glucosidase activities from the clinical isolates of Candida species.Jpn J Infect Dis.,59,73-76.
Calderone, RA(ed.)(2002).Candida and Candidiasis.Washington, DC:ASM Press.

被引用文献 ( 1 ) 〈TOP〉

Shimaa El-Sapagh,Sameh S. Ali,Rania Al-Tohamy,Nessma A. El-Zawawy,Jianzhong Sun,Ahmed M. Mustafa(2020).Lycium shawii Roem. & Schult.: A new bioactive antimicrobial and antioxidant agent to combat multi-drug/pan-drug resistant pathogens of wound burn infections.Journal of Traditional and Complementary Medicine,10(1),13-25.

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