高血糖鼠燒燙傷口纖維母細胞與轉化生長因子β1分泌之相關性

呂麗嫦

doi:10.6840/cycu201600840

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高血糖鼠烧烫伤口纤维母细胞与转化生长因子β1分泌之相关性

THE CORRELATION BETWEEN FIBROBLAST AND THE SECRETION OF TGF-β1 IN THE BURNS OF HYPERGLYCEMIC RATS

吕丽嫦 , 硕士　　导师：谢瑞香;吴木荣　　

繁体中文 DOI： 10.6840/cycu201600840

高血糖鼠；发光二极体；伤口癒合； TGF-β1 ； Hyperglycemic ； TGF-β1 ； Wound healing ； Light emitting diode

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摘要 │ 参考文献 (37) │ 国际计量

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Chronic inflammation process is highly associating to hyperglycemic patients; however, Low Level Light Therapy (LLLT) have been proven that is able to increase the quantity of collagen fiber aggregation around the wound, also stimulating perfusion of the wounding area. TGF-β1 proliferate is able to synthesis of fibroblast and collagen during the wound healing process. In this research we choose 300-325 g male Wistar Rat as our study material, using Alloxan monohydrate (80~100 mg/kg) induce to hyperglycemic individual via Intraperitoneal injection pathway, and we create 1 cm2 scald on the dorsal side of the hyperglycemic Rat. Afterwards irradiate LED (630nm, 14 mW/cm2, 4 J/cm2) on the wound area of the hyperglycemic Rat. Studying the correlation between fibroblast and the secretion of TGF-β1 in the burns of hyperglycemic Rat. In consequence the maximum fibroblasts numbers are around at 681±53 two weeks after healing in normal rat with LED therapy on the burned wound. Yet, the maximum fibroblast numbers of hyperglycemic wounded rat with LED therapy are approximately 547±78 after 16 days. Thus the cells of both hyperglycemic and normal rat under LED therapy are grown faster than those rats without LED therapy. Additionally, the normal with LED therapy rat number of TGF-β1 reach to 553±63 pg/ml in 4 days. Significantly two days faster than those without LED healing; however the hyperglycemic rat which treated by LED illumination increase the TGF-β1 numbers on the wound area, with the maximum quantity 759±210 pg/ml on 12th day, faster than those without LED therapy. According to the result above the hyperglycemic rat treated with LED therapy afterwards indeed increase the secretion of TGF-β1 initially, then decrease the level in the end of the healing period. Meanwhile LED therapeutic also induce the fibroblast number of the hyperglycemic rat, reaching to the maximum number two days faster. In other words shortening 2 days of the wound healing process. Therefore we hypothesis the amount of TGF-β1 secretion is associate to the number of fibroblast proliferate. Further more LED therapy truly help hyperglycemic rat move on wound healing process.

参考文献 ( 37 ) 〈TOP〉

1. Al-Watban, F. A., X. Y. Zhang and B. L. Andres (2007). "Low-level laser therapy enhances wound healing in diabetic rats: a comparison of different lasers." Photomedicine and laser surgery 25(2): 72-77.
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2. AlGhamdi, K. M., A. Kumar and N. A. Moussa (2012). "Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells." Lasers in medical science 27(1): 237-249.
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3. Bibikova, A. and U. Oron (1993). "Promotion of muscle regeneration in the toad (Bufo viridis) gastrocnemius muscle by low-energy laser irradiation." Anat Rec 235: 374-380.
连结：
4. Bolten, P., S. Young and M. Dyson (1995). "The direct effect of 860 nm light on cell proliferation and on succinic dehydrogenase activity of human fibroblasts in vitro." Laser Therapy 7: 55-60.
连结：
5. Byrnes, K. R., X. J. Wu, R. W. Waynant, I. K. Ilev and J. J. Anders (2005). "Low power laser irradiation alters gene expression of olfactory ensheathing cells in vitro." Lasers in Surgery and Medicine 37(2): 161-171.
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引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。