以資料視覺化進行探索性資料分析:以探討多重用藥相關因素為例

羅凱威

doi:10.6342/NTU201800369

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以资料视觉化进行探索性资料分析:以探讨多重用药相关因素为例

Exploratory Data Analysis with Data Visualization:Taking Polypharmacy as an Example

罗凯威 , 硕士　　导师：杜裕康　　

繁体中文 DOI： 10.6342/NTU201800369

多重用药；健康检查；多元逻辑斯回归；广义相关图； polypharmacy ； health check-up ； multinomial logistic regression ； generalized association plot

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摘要 │ 参考文献 (54) │ 国际计量

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Introduction

The drug expenditure in Taiwan has always been a significant part of the total medical costs, and the drug expenditure percentage of the total medical expenses is higher than the other countries. With such large drug usage, medication problems are derived, such as drug interactions and therapeutic duplications, etc… Besides, these problems have a close relationship with polypharmacy. The so-called polypharmacy refers to taking multiple types of drug simultaneously, or overuse drugs more than the required ones. This thesis will utilize the information provided by the health check-up database to explore the status and the related factors of polypharmacy in Taiwan.

Objective

This study will use the health check-up reports and questionnaire data of MJ 
(1) to understand the prevalence of polypharmacy in adults (2) besides the common factors, gender and age, to confirm the relationship between factors as education level, region, unhealthy habits, biochemical test, and the result, polypharmacy (3) to explore the similarity and difference of drug usage combination among people in different age groups with polypharmacy by clustering and sorting algorithms.

Materials and Methods

The health check-up database provided by MJ is in Taiwan from 2000 to 2006. It can be divided into two parts: questionnaire data and health check-up reports. About the research methods, in addition to the traditional statistical charts, generalized association plot(GAP) is applied to explore the similarity and difference between the subject's drug combination. As for inferential statistics, the multinomial logistic regression and binary logistic regression are the methods for model building.
 
Results

According to the logistic regression analysis, it is found that female subjects, subjects without college degree, and subjects having meals irregularly are higher risk groups for polypharmacy. In addition, the polypharmacy odds for patients taking medicine of heart disease and hyperlipidemia is 10 times higher than that do not. Furthermore, the relationship between Chinese medicine usage and polypharmacy is negative.

In the polypharmacy subjects of all age groups, drug clustering analysis shows that in 20-44- years- old and 45-64-year-old subjects with polypharmacy, a group of mostly female clusters who prefer to take sleeping pills, Chinese medicine, analgesic and gastrointestinal drugs were summarized separately. In contrast, in the male majority drug cluster, the preference for taking antihypertensive, hypolipidemic and antidiabetic agents is high. As for subjects over the age of 65, sleeping pills and Chinese medicine users as well as analgesic users form two obvious drug clusters.

参考文献 ( 54 ) 〈TOP〉

2.卫生福利部:中央健康保险署. 健保公布103年各年龄层药费及医疗费用分布情形. 2015 2015.10.07; Available from: https://www.nhi.gov.tw/News_Content.aspx?n=A7EACB4FF749207D&sms=587F1A3D9A03E2AD&s=1C70EFC8E5FD1DD2.
连结：
5.吴岱颖, et al., 老年人过度多重用药与药物不良反应：个案报告. 台湾老年医学暨老年学杂志, 2010. 5(2): p. 130-138.
连结：
6.陈韦良, et al., 老年人的多重用药. 当代医学, 2008(415): p. 378-385.
连结：
7.Balogun, S., M. Preston, and J. Evans, Potentially inappropriate medications in nursing homes: sources and correlates. The Internet Journal of Geriatrics and Gerontology, 2005. 2(2).
连结：
8.Moore, K.J., et al., Public sector residential aged care: identifying novel associations between quality indicators and other demographic and health-related factors. Australian Health Review, 2014. 38(3): p. 325-331.
连结：

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使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。