血塊受旋轉剪應力下之力學分析

孫瑞鴻

doi:10.6342/NTU201701105

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血块受旋转剪应力下之力学分析

Mechanics of rotation-induced shear on blood clot under suction

孙瑞鸿 , 硕士　　导师：施文彬　　

英文 DOI： 10.6342/NTU201701105

血块；接触力学；破坏；吸； Blood clot ； contact mechanics ； fracture ； suction

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摘要 │ 参考文献 (44) │ 国际计量

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Intracerebral hemorrhage is also known as cerebral bleed. Rapid increase pressure can cause unconsciousness or death. Victims of intracerebral hemorrhage are suggested to receive medical treatment immediately. One of the common treatment is thrombolysis using medicine. However, certain criterion should be met by the patients and side effects could be caused by the medicine. While performing minimal invasive surgery, the blood clot in the head can clog the aspiration tube. This requires surgeon to take to the tube and clean it. This process wastes the precious time. A solution to this problem can save lots of people.
Based on observation, the clog inside the tube can be avoided by choosing low friction tube and most clots clog at the tip. Most of current solutions are combining medicine or electrical-driven component. The mechanical solution and the mechanism are worth investigating because drugs could have side effects and electric driven mechanism may have risk of electricity leaking. Further analysis of the mechanism between suction tube and blood clot is needed.
The stress components on the contact surface of blood clot are important for crack initiation. Traditional penny shaped crack model and 3-D punch is investigated. From Reissner-Sagoci and punch problem, the shear stress on the surface can be derived. Combining the traditional models and finite element analysis of stress intensity factor, the stress field of pure suction and suction with rotational tip can be approximated by proposed equation.
Specially designed experiments were conducted to measure the blood clot elastic modulus by tensile test and viscus modulus by relaxation test. A suction test is studied to compare a normal tip, a sharp thin edge tip and a rotational sharp thin tip by aspirate agar blocks which simulate blood clots. The result is that with a rotational tip, the pressure required to clean the clots can be reduced.
This study combines several traditional model and finite element results of stress intensity factor to approximate the stress field of a blood clot under rotating suction tip. A dedicated experiment for soft materials are done to measure the material constant of blood clot. Then, a rotating suction tip is proved to be more effective than the normal tip by reducing the pressure requirement.

参考文献 ( 44 ) 〈TOP〉

[3] W. Hacke, et al.(1995) “Intravenous Thrombolysis With Recombinant Tissue Plasminogen Activator For Acute Hemispheric Stroke,” The European Cooperative Acute Stroke Study (ECASS). JAMA 274(13):1017,
连结：
[4] G.A. ,Donnan.(1996) “Streptokinase for acute ischemic stroke with relationship to time of administration: Australian Streptokinase (ASK).” Trial Study Group. JAMA 276(12):961-6,
连结：
[5] D. J. Miller, J. R. Simpson, & B. Silver, (2011). ”Safety of Thrombolysis in Acute Ischemic Stroke: A Review of Complications, Risk Factors, and Newer Technologies.” The Neurohospitalist, 1(3), 138–147. Available: http://doi.org/10.1177/1941875211408731
连结：
[7] J. C. Hemphill, 3rd; S. M. Greenberg; C. S. Anderson; K. Becker; B. R. Bendok, M. Cushman; G. L. Fung, J. N. Goldstein; R.L. Macdonald; P. H. Mitchell; P.A. Scott, M. H. Selim,; D. Woo; (2015). “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.” Stroke; a journal of cerebral circulation. 46 (7): 2032–60.
连结：
[9] K. Badran, P. Karkos, (2007), “Recurrent blockage of the sucker during otological surgery: a simple solution,” J Laryngol Otol. 2007;121:266–7.
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引用含有DOI的文献

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DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。