以凝膠法製備海藻酸鈣微膠囊包覆樟腦油及其釋放性之研究

Preparation and Release Properties of Alginate Microcapsules Encapsulated Camphor Oil

10.29984/JHGT.200809.0009

楊鈺貞(Y. Z. Yang)；高韻棽(Y. L. Gao)；賴政延(C. Y. Lai)；黃國雄(G. X. Huang)；柯光裕(G. Y. Ke)；張志鵬(C. P. Chang)

簡單凝膠法 ； 海藻酸微膠囊 ； 控制制放 ； simple coacervation ； alginate microcapsules ； controlled release

華岡紡織期刊

15卷3期（2008 / 09 / 01）

283 - 291

繁體中文

本研究使用樟腦油為芯材，海藻酸納為殼材，利用簡單凝膠法來製作海藻酸鈣微膠囊。且採用兩段式製作微膠囊，藉由第一階段和第二階段轉速之不同，分別探討微膠囊之成形性、制放性與粒徑大小。結果顯示採用2%海藻酸鍋溶液與5%氯化鈣溶液並以Tween20為界面活性劑，於第一階段轉速在22000rpm，第二階段轉速在22000rpm下交鏈10min後所製得之微膠囊其平均粒徑為76±4.9μm，此製造條件為本研究所設定範圍內之最佳條件。在此條件下確認樟腦油經微膠囊包覆後能夠有效的控制其制放速率，並達到定時定量的緩釋效果。

In this study, sodium alginate used as wall material and camphor oil used as core material, the possibility of manufacturing microcapsule by two steps process was discussed. The various stirring speeds between the first step and the second step was discussed the formation, control release and particle size between of by two stirring speeds. The results indicated that the optimal conditions of morphology were the concentration of wall material 2%, and CaC12 5% of surfactant Tween20. The optimal manufacturing of alginate microcapsules condition was the cross-linking time was 10 minutes in the stirring speed of first step at 22000rpm and the stirring speed of second step at 22000rpm. The average particle size was 76±4.9μm.

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