登山期間口服硫化脫氫異雄固酮鹽對生心理壓力指標及肌肉流失的影響

楊孫錦; 李文志; 侯建文; 王三財; 林勁宏

doi:10.6194/SCS.2014.36.05

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P47 - 63

社会科学 > 体育学

DOI： 10.6194/SCS

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登山期间口服硫化脱氢异雄固酮盐对生心理压力指标及肌肉流失的影响

The Effect of Oral Dehydroepiandrosterone on Physiological Psychology Index and Muscle Loss during Mountain Climbing

杨孙锦(Sun-Chin Yang) ；李文志(Wen-Chih Lee) ；侯建文(Chien-Wen Hou) ；王三财(San-Tsai Wang) ；林劲宏(Ching-Hung Lin)

运动教练科学； 36 期 (2014 / 12 / 01) ， P47 - 63

繁体中文 DOI： 10.6194/SCS.2014.36.05

低氧；可体松；睾固酮； hypoxia ； cortisol ； testosterone

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摘要 │ 参考文献 (33) │ 被引用文献 (1) │ 国际计量

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Purpose: this study aims to investigate the effect of oral dehydroepiandrosterone (DHEA) on physiological psychology index and muscle loss after the short-term high altitude mountain climbing. Method: 14 health volunteers (32.9±6.97 yrs old) were divided to placebo and DHEA groups by body weight balance. The pre-test included body composition, insulin sensitivity, and blood biochemical marker was carried out at first day, subsequently started taking inulin placebo (control group) or DHEA (DHEA group) until the fifth day. The mountaineering activities was implemented during third to fifth day and the post-test was carried out at sixth day. Besides the response of acute mountain sickness and heart rate were measured. Result: the mountain sickness self-assessment scores of both groups on the second day were significantly higher than the first and third day of mountaineering activities. The concentration of DHEA sulfate (DHEAS) in DHEA group was significantly higher at post- than pre-test, (5.76±0.48 vs 3.22±0.36 ng/dl, p＜.05), and higher than control group at pre-test (5.76±0.48及2.75±0.20 ng/dl, p＜.05). The cortisol level of both groups was higher at post- than pre-test, but not different between groups at post-test. The ratio of cortisol and DHEAS in control group was significantly higher at postthan pre-test (6.10±0.55 vs 5.29±1.07, p ＜ .05), and higher than DHEA group at pre-test (6.10±0.55 vs 3.43±0.47, p ＜ .05). The fat mass and testosterone level of both groups was lower at post- than pre-test, but not different between groups. Tumor necrosis factor-α and HOMA-IR index were not different between groups at postand pre-test. Conclusion: The main finding of this study that the ability of resistance for physiological psychology stress was increased by DHEA supplementation during mountain climbing, but not affected muscle loss.

参考文献 ( 33 ) 〈TOP〉

Barnholt, K. E.,Hoffman, A. R.,Rock, P. B.,Muza, S. R.,Fulco, C. S.,Braun, B.(2006).Endocrine responses to acute and chronic high-altitude exposure (4,300 meters): Modulating effects of caloric restriction.The American Journal of Physiology-Endocrinology and Metabolism,290(6),E1078-1088.
Baumgartner, R. N.,Waters, D. L.,Gallagher, D.,Morley, J. E.,Garry, P. J.(1999).Predictors of skeletal muscle mass in elderly men and women.Mechanisms of Ageing and Development,107(2),123-136.
Bhasin, S.(2003).Testosterone supplementation for aging-associated sarcopenia.Journals of Gerontology Series A, Biological Sciences and Medical Sciences,58(11),1002-1008.
Binello, E.,Gordon, C. M.(2003).Clinical uses and misuses of dehydroepiandrosterone.Current Opinion in Pharmacology,3(6),635-641.
Bolmont, B.,Thullier, F.,Abraini, J. H.(2000).Relationships between mood states and performances in reaction time, psychomotor ability, and mental efficiency during a 31-day gradual decompression in a hypobaric chamber from sea level to 8,848 m equivalent altitude.Physiology and Behavior,71(5),469-476.

被引用文献 ( 1 ) 〈TOP〉

郑钧任、曾文培(2016)。急性高山症之生理反应及药物治疗。大专体育，137，54-61。

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