山苦瓜改善高脂飲食誘發小鼠代謝異常、脂肪肝與肝相關基因 mRNA 表現

董又慈

doi:10.6342/NTU201601776

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山苦瓜改善高脂饮食诱发小鼠代谢异常、脂肪肝与肝相关基因 mRNA 表现

Wild bitter gourd ameliorates high-fat diet induced metabolic disorder, fatty liver and hepatic mRNA expressions of related genes in C57BL/6J mice.

董又慈 , 硕士　　导师：黄青真　　

繁体中文 DOI： 10.6342/NTU201601776

山苦瓜；肝脏；脂质代谢；粒线体；非酒精性脂肪肝； wild bitter gourd ； liver ； lipid metabolism ； mitochondria ； non-alcoholic fatty liver

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摘要 │ 参考文献 (111) │ 被引用文献 (2) │ 国际计量

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The prevalence of obesity and metabolic disorders over the world increases in recent decades, as a result of changes in the diet and life style. Obesity are linked to high risks of many chronic diseases, such as metabolic syndrome, non-alcoholic fatty liver disease, and type 2 diabetes, etc. It has thus become a key issue in public health. Previous studies demonstrated that wild bitter gourd extracts activate PPARα in a transactivation assay and active compounds have been identified. PPARα is known to regulate hepatic lipid metabolism by up-regulating genes of some metabolic pathway and leading to enhanced fatty acid oxidation, less fat accumulation, etc. In addition, wild bitter gourd can improve hyperglycemia through various mechanisms. Recent in vivo studies in our lab demonstrated that mice fed 5% wild bitter gourd powder (BGP) increased the energy expenditure by promoting hepatic fatty acid metabolism, browning of epididymal white adipose tissue and the function of mitochondria in skeletal muscle and white adipose tissue; thus, wild bitter gourd can ameliorate the obesity and the insulin resistance resulting from a high-sugar or high-fat diet. This study aims to examine effects of wild bitter gourd supplementation to high-fat diet induced obese mice on serum glucose and lipid, as well as the mRNA expressions of the hepatic lipid metabolism and hepatic mitochondrial function.
Five groups of C57BL/6J male mice were fed an AIN-93G modified high-fat diet for 15 weeks and then followed by supplementing 0%, 3% BGP, 5% BGP, 3% hydrolyzed BGP (BGPa) or 5% BGPa in high-fat diet respectively. Our data suggests that the supplement of wild bitter gourd improve metabolic disorders induced by the high-fat diet, including obesity, hyperglycemia, hypercholesterolemia, and non-alcoholic fatty liver disease. BGP and BGPa can both decrease the hepatic lipid accumulation by increasing the mRNA expression levels of genes related to fatty acid oxidation through activating hepatic PPARα. Noticeably, only BGPa can up-regulate the mRNA expression level of the gene related to bile acid synthesis possibly by activating hepatic LXRα. These data suggested that BGPa might have additional benefit improving the hepatic cholesterol accumulation. In addition, the function of BGPa to ameliorate the down-regulated mRNA expression level of genes related to mitochondrial biogenesis, fusion and fission due to the high-fat diet is significantly better than BGP.
In conclusion, wild bitter gourd may alleviate the metabolic disorder from the high-fat diet by facilitating the hepatic fatty acid catabolism and promoting mitochondrial activity. Also, wild bitter gourd hydrolyzed by its endogenous glucosidase enhances its ability to improve the hepatic cholesterol accumulation and increase the mRNA expression level of genes related to hepatic mitochondrial function. Based on this, BGPa ameliorates the obesity-induced non-alcoholic fatty liver more effectively than BGP.

参考文献 ( 111 ) 〈TOP〉

Abdelmegeed, M. A., Yoo, S. H., Henderson, L. E., Gonzalez, F. J., Woodcroft, K. J., & Song, B. J. (2011). PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. J Nutr, 141(4), 603-610.
连结：
Alam, M. A., Uddin, R., Subhan, N., Rahman, M. M., Jain, P., & Reza, H. M. (2015). Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids, 2015, 496169.
连结：
Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006). The metabolic syndrome—a new worldwide definition. The Lancet, 366(9491), 1059-1062.
连结：
Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013). Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov, 12(6), 465-483.
连结：
Ashtari, S., Pourhoseingholi, M. A., & Zali, M. R. (2015). Non-alcohol fatty liver disease in Asia: Prevention and planning. World J Hepatol, 7(13), 1788-1796.
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DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。